I was trying out Avdi Grimm's Quarto a week or so back for ebook generation. The toolchain looks very promising, but has a few dependencies that need to be installed before you can start publishing. These are listed in the README.
Here's a quick guide in getting those installed on OSX (Mountain Lion). Note I already had the following setup:
Command line instructions:
The big one here is to ensure ~/.cabal/bin is in your path when you run the rake task to publish.